GrippeAllemagneV4, Main, Exploration, bibRecord, 000051

Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.

Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052

Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.

Auteurs : André Kidszun [Allemagne] ; Lena Klein [Allemagne] ; Julia Winter [Allemagne] ; Isabella Schmeh [Allemagne] ; Britta Gröndahl [Allemagne] ; Stephan Gehring [Allemagne] ; Markus Knuf [Allemagne] ; Kerstin Weise [Allemagne] ; Eva Mildenberger [Allemagne]

Source :

American journal of perinatology [ 1098-8785 ] ; 2017.

RBID : pubmed:27182999

Descripteurs français

English descriptors

Abstract

Objective The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. Methods In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, and picornavirus. Stools were examined for adenovirus, rotavirus, norovirus, and enterovirus. Results Between August 2010 and March 2014, data of 88 infants with 137 episodes of suspected late-onset bacterial sepsis were analyzed. Six infants were diagnosed with a respiratory viral infection (2 × RSV, 4 × picornavirus). Blood culture-proven bacterial sepsis was detected in 15 infants. Neither viral-bacterial coinfections nor polymerase chain reaction positive stool samples were found. Conclusion Respiratory viruses can be detected in a considerable number of neonates with suspected late-onset bacterial sepsis. In contrast, gastrointestinal viral or enterovirus infections appear uncommon in such cases.

DOI: 10.1055/s-0036-1584150
PubMed: 27182999
PubMed Central: PMC7171717

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenovirus Infections, Human (diagnosis)</term>
<term>Adenovirus Infections, Human (epidemiology)</term>
<term>Bacteremia (diagnosis)</term>
<term>Bacteremia (epidemiology)</term>
<term>Blood Culture (MeSH)</term>
<term>Caliciviridae Infections (diagnosis)</term>
<term>Caliciviridae Infections (epidemiology)</term>
<term>Cohort Studies (MeSH)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Enterovirus Infections (diagnosis)</term>
<term>Enterovirus Infections (epidemiology)</term>
<term>Enzyme-Linked Immunosorbent Assay (MeSH)</term>
<term>Feces (virology)</term>
<term>Female (MeSH)</term>
<term>Germany (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Infant, Newborn (MeSH)</term>
<term>Influenza, Human (diagnosis)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Intensive Care Units, Neonatal (MeSH)</term>
<term>Late Onset Disorders (MeSH)</term>
<term>Male (MeSH)</term>
<term>Multiplex Polymerase Chain Reaction (MeSH)</term>
<term>Nasopharynx (virology)</term>
<term>Neonatal Sepsis (diagnosis)</term>
<term>Neonatal Sepsis (epidemiology)</term>
<term>Paramyxoviridae Infections (diagnosis)</term>
<term>Paramyxoviridae Infections (epidemiology)</term>
<term>Picornaviridae Infections (diagnosis)</term>
<term>Picornaviridae Infections (epidemiology)</term>
<term>Prospective Studies (MeSH)</term>
<term>Respiratory Syncytial Virus Infections (diagnosis)</term>
<term>Respiratory Syncytial Virus Infections (epidemiology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Rotavirus Infections (diagnosis)</term>
<term>Rotavirus Infections (epidemiology)</term>
<term>Virus Diseases (diagnosis)</term>
<term>Virus Diseases (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term>
<term>Bactériémie (diagnostic)</term>
<term>Bactériémie (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Fèces (virologie)</term>
<term>Grippe humaine (diagnostic)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Hémoculture (MeSH)</term>
<term>Infections humaines à adénovirus (diagnostic)</term>
<term>Infections humaines à adénovirus (épidémiologie)</term>
<term>Infections à Caliciviridae (diagnostic)</term>
<term>Infections à Caliciviridae (épidémiologie)</term>
<term>Infections à Paramyxoviridae (diagnostic)</term>
<term>Infections à Paramyxoviridae (épidémiologie)</term>
<term>Infections à Picornaviridae (diagnostic)</term>
<term>Infections à Picornaviridae (épidémiologie)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Infections à entérovirus (diagnostic)</term>
<term>Infections à entérovirus (épidémiologie)</term>
<term>Infections à rotavirus (diagnostic)</term>
<term>Infections à rotavirus (épidémiologie)</term>
<term>Infections à virus respiratoire syncytial (diagnostic)</term>
<term>Infections à virus respiratoire syncytial (épidémiologie)</term>
<term>Maladies virales (diagnostic)</term>
<term>Maladies virales (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>RT-PCR (MeSH)</term>
<term>Réaction de polymérisation en chaine multiplex (MeSH)</term>
<term>Sepsis néonatal (diagnostic)</term>
<term>Sepsis néonatal (épidémiologie)</term>
<term>Test ELISA (MeSH)</term>
<term>Troubles tardifs (MeSH)</term>
<term>Unités de soins intensifs néonatals (MeSH)</term>
<term>Études de cohortes (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Adenovirus Infections, Human</term>
<term>Bacteremia</term>
<term>Caliciviridae Infections</term>
<term>Coronavirus Infections</term>
<term>Enterovirus Infections</term>
<term>Influenza, Human</term>
<term>Neonatal Sepsis</term>
<term>Paramyxoviridae Infections</term>
<term>Picornaviridae Infections</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Rotavirus Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Bactériémie</term>
<term>Grippe humaine</term>
<term>Infections humaines à adénovirus</term>
<term>Infections à Caliciviridae</term>
<term>Infections à Paramyxoviridae</term>
<term>Infections à Picornaviridae</term>
<term>Infections à coronavirus</term>
<term>Infections à entérovirus</term>
<term>Infections à rotavirus</term>
<term>Infections à virus respiratoire syncytial</term>
<term>Maladies virales</term>
<term>Sepsis néonatal</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Adenovirus Infections, Human</term>
<term>Bacteremia</term>
<term>Caliciviridae Infections</term>
<term>Coronavirus Infections</term>
<term>Enterovirus Infections</term>
<term>Germany</term>
<term>Influenza, Human</term>
<term>Neonatal Sepsis</term>
<term>Paramyxoviridae Infections</term>
<term>Picornaviridae Infections</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Rotavirus Infections</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term>
<term>Partie nasale du pharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term>
<term>Nasopharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term>
<term>Bactériémie</term>
<term>Grippe humaine</term>
<term>Infections humaines à adénovirus</term>
<term>Infections à Caliciviridae</term>
<term>Infections à Paramyxoviridae</term>
<term>Infections à Picornaviridae</term>
<term>Infections à coronavirus</term>
<term>Infections à entérovirus</term>
<term>Infections à rotavirus</term>
<term>Infections à virus respiratoire syncytial</term>
<term>Maladies virales</term>
<term>Sepsis néonatal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Blood Culture</term>
<term>Cohort Studies</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Infant, Newborn</term>
<term>Intensive Care Units, Neonatal</term>
<term>Late Onset Disorders</term>
<term>Male</term>
<term>Multiplex Polymerase Chain Reaction</term>
<term>Prospective Studies</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Hémoculture</term>
<term>Mâle</term>
<term>Nouveau-né</term>
<term>RT-PCR</term>
<term>Réaction de polymérisation en chaine multiplex</term>
<term>Test ELISA</term>
<term>Troubles tardifs</term>
<term>Unités de soins intensifs néonatals</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><b>Objective</b>
 The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. <b>Methods</b>
 In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, and picornavirus. Stools were examined for adenovirus, rotavirus, norovirus, and enterovirus. <b>Results</b>
 Between August 2010 and March 2014, data of 88 infants with 137 episodes of suspected late-onset bacterial sepsis were analyzed. Six infants were diagnosed with a respiratory viral infection (2 × RSV, 4 × picornavirus). Blood culture-proven bacterial sepsis was detected in 15 infants. Neither viral-bacterial coinfections nor polymerase chain reaction positive stool samples were found. <b>Conclusion</b>
 Respiratory viruses can be detected in a considerable number of neonates with suspected late-onset bacterial sepsis. In contrast, gastrointestinal viral or enterovirus infections appear uncommon in such cases.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27182999</PMID>
<DateCompleted><Year>2018</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-8785</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>34</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>American journal of perinatology</Title>
<ISOAbbreviation>Am J Perinatol</ISOAbbreviation>
</Journal>
<ArticleTitle>Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.</ArticleTitle>
<Pagination><MedlinePgn>1-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1055/s-0036-1584150</ELocationID>
<Abstract><AbstractText><b>Objective</b>
 The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. <b>Methods</b>
 In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, and picornavirus. Stools were examined for adenovirus, rotavirus, norovirus, and enterovirus. <b>Results</b>
 Between August 2010 and March 2014, data of 88 infants with 137 episodes of suspected late-onset bacterial sepsis were analyzed. Six infants were diagnosed with a respiratory viral infection (2 × RSV, 4 × picornavirus). Blood culture-proven bacterial sepsis was detected in 15 infants. Neither viral-bacterial coinfections nor polymerase chain reaction positive stool samples were found. <b>Conclusion</b>
 Respiratory viruses can be detected in a considerable number of neonates with suspected late-onset bacterial sepsis. In contrast, gastrointestinal viral or enterovirus infections appear uncommon in such cases.</AbstractText>
<CopyrightInformation>Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kidszun</LastName>
<ForeName>André</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klein</LastName>
<ForeName>Lena</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winter</LastName>
<ForeName>Julia</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmeh</LastName>
<ForeName>Isabella</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gröndahl</LastName>
<ForeName>Britta</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gehring</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Knuf</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weise</LastName>
<ForeName>Kerstin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute for Virology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mildenberger</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>05</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Perinatol</MedlineTA>
<NlmUniqueID>8405212</NlmUniqueID>
<ISSNLinking>0735-1631</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
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<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016470" MajorTopicYN="N">Bacteremia</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071997" MajorTopicYN="N">Blood Culture</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017250" MajorTopicYN="N">Caliciviridae Infections</DescriptorName>
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<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
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</MeshHeading>
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</MeshHeading>
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<affiliations><list><country><li>Allemagne</li>
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<region><li>Rhénanie-Palatinat</li>
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<settlement><li>Mayence</li>
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<tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Kidszun, Andre" sort="Kidszun, Andre" uniqKey="Kidszun A" first="André" last="Kidszun">André Kidszun</name>
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<name sortKey="Gehring, Stephan" sort="Gehring, Stephan" uniqKey="Gehring S" first="Stephan" last="Gehring">Stephan Gehring</name>
<name sortKey="Grondahl, Britta" sort="Grondahl, Britta" uniqKey="Grondahl B" first="Britta" last="Gröndahl">Britta Gröndahl</name>
<name sortKey="Klein, Lena" sort="Klein, Lena" uniqKey="Klein L" first="Lena" last="Klein">Lena Klein</name>
<name sortKey="Knuf, Markus" sort="Knuf, Markus" uniqKey="Knuf M" first="Markus" last="Knuf">Markus Knuf</name>
<name sortKey="Mildenberger, Eva" sort="Mildenberger, Eva" uniqKey="Mildenberger E" first="Eva" last="Mildenberger">Eva Mildenberger</name>
<name sortKey="Schmeh, Isabella" sort="Schmeh, Isabella" uniqKey="Schmeh I" first="Isabella" last="Schmeh">Isabella Schmeh</name>
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Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.

Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study.

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